Plant extracts and phytochemicals in canine and feline mammary cancer models

저자: Patergiannakis Iason-Spyridon; Pappas Ioannis S
출처: Veterinary research communications, 2026
DOI/링크: 10.1007/s11259-026-11336-8
분야 태그: #반려동물 #천연물효능
정리일: 2026-07-11

TL;DR

This review summarizes current knowledge on plant extracts and phytochemicals in canine and feline mammary tumors, focusing on their preclinical evidence, limitations, and future translational challenges in veterinary oncology

1. 연구 배경 및 동기

다루는 문제: Mammary tumors are among the most common neoplasms in dogs and cats, and malignant forms are clinically important in both species
기존의 공백 / 왜 필요한가: Surgery remains the main treatment approach and may be combined with other treatment modalities, but advanced cases are often associated with recurrence and limited responsiveness to conventional therapies. Phytochemicals and plant extracts have received attention as potential adjuvant agents that can modulate pathways associated with oncogenesis and treatment resistance

2. 관련 연구

기존 연구 흐름: Natural products are often accessible and relatively inexpensive, and their perception as well-tolerated agents may increase owner acceptance
이 논문의 위치: Natural Product Efficacy Evaluation 분야 내 기존 문헌 검토

구분	기존 연구	이 논문
주제	일반적 접근	Plant 중심

3. 핵심 기여

Further studies are required for clinical translation, as species-specific pharmacokinetics significantly affect efficacy and safety
This review summarizes current knowledge on plant extracts and phytochemicals in canine and feline mammary tumors, focusing on their preclinical evidence, limitations, and future translational challenges in veterinary oncology.

4. 제안 방법론

전체 접근 논리: Some plant extracts and phytochemicals, including Euphorbia royleana extract, celastrol, and homoharringtonine have shown potent preclinical activity in canine mammary tumor cell lines and xenograft models, but data for feline mammary tumors are still limited
단계: However, their safety and efficacy depend on multiple factors such as the compound, dose, formulation, and species

5. 실험 설정

항목	내용
대상/재료	Some plant extracts and phytochemicals, including Euphorbia royleana extract, celastrol, and homoharringtonine have shown potent preclinical activity in
처리 조건	However, their safety and efficacy depend on multiple factors such as the compound, dose, formulation, and species
대조군	-
측정 방법	However, their safety and efficacy depend on multiple factors such as the compound, dose, formulation, and species

6. 실험 결과 분석

지표	변화(Δ)	조건 · 유의성
-	-	Further studies are required for clinical translation, as species-specific pharmacokinetics significantly affect efficacy and safety

제안 기전(인과 사슬): Further studies are required for clinical translation, as species-specific pharmacokinetics significantly affect efficacy and safety

7. 비판적 평가

강점

This review summarizes current knowledge on plant extracts and phytochemicals in canine and feline mammary tumors, focusing on their preclinical evidence, limitations, and future translational challenges in veterinary oncology.

한계 · 의문

표본 크기 및 장기 추적 데이터 부재 가능성

8. 향후 연구 방향

This review summarizes current knowledge on plant extracts and phytochemicals in canine and feline mammary tumors, focusing on their preclinical evidence, limitations, and future translational challenges in veterinary oncology.

9. 결론

Mammary tumors are among the most common neoplasms in dogs and cats, and malignant forms are clinically important in both species 연구에서 some plant extracts and phytochemicals, including euphorbia royleana extract, celastrol, and homoharringtonine have shown potent preclinical activity in canine mammary tumor cell lines and xenograft models, but data for feline mammary tumors are still limited을 통해 further studies are required for clinical translation, as species-specific pharmacokinetics significantly affect efficacy and safety. This review summarizes current knowledge on plant extracts and phytochemicals in canine and feline mammary tumors, focusing on their preclinical evidence, limitations, and future translational challenges in veterinary oncology

Keywords

Plant, extracts, phytochemicals, canine, feline, mammary