Prevalence of POMC allele associated with obesity in feline population in Vietnam
Prevalence of POMC allele associated with obesity in feline population in Vietnam
- 저자: Vu Thao Phuong; Le Thong Quang; Truong Truc Thi Thanh; Duong Cuong Ngoc; Dang Han Thi Ngoc; Phan Huynh Nhat; Bui Anh Phu Nam
- 출처: Research in veterinary science, 2026
- DOI/링크: 10.1016/j.rvsc.2026.106222
- 분야 태그: #반려동물 #동물영양
- 정리일: 2026-07-11
TL;DR
These findings suggest that the POMC c.28G > C variant is a useful risk-informative marker and that combining genetic screening with objective fat assessment may support earlier identification and prevention of feline obesity in Vietnam under routine laboratory conditions and guide personalized management strategies in practice
1. 연구 배경 및 동기
- 다루는 문제: Feline obesity is an increasingly important health problem influenced by both genetic predisposition and husbandry practices
- 기존의 공백 / 왜 필요한가: This study investigated the prevalence and phenotypic relevance of the feline proopiomelanocortin (POMC) c.28G > C (p.Gly10Arg) variant in a Vietnamese cat population and evaluated environmental factors associated with obesity. A total of 63 clinically healthy cats were classified as normal weight (body condition score [BCS] 5-6/9; n = 40) or obese (BCS ≥7/9; n = 23)
2. 관련 연구
- 기존 연구 흐름: Genotyping was performed using a newly developed PCR-restriction fragment length polymorphism assay and validated by Sanger sequencing
- 이 논문의 위치: Animal Nutrition 분야 내 기존 문헌 검토
| 구분 | 기존 연구 | 이 논문 |
|---|---|---|
| 주제 | 일반적 접근 | Prevalence 중심 |
3. 핵심 기여
- Neuter status and ad libitum feeding were significantly associated with obesity, whereas diet type, housing, exercise frequency, and begging behavior were not
- Although genotype distribution did not differ significantly between normal and obese cohorts, obese CC cats showed significantly greater VSAT thickness than obese GC cats, indicating an allele-dosage effect on adiposity
- These findings suggest that the POMC c.28G > C variant is a useful risk-informative marker and that combining genetic screening with objective fat assessment may support earlier identification and prevention of feline obesity in Vietnam under routine laboratory conditions and guide personalized management strategies in practice.
4. 제안 방법론
- 전체 접근 논리: Ventral subcutaneous adipose tissue (VSAT) thickness was measured ultrasonographically as an objective indicator of adiposity
- 단계: Genotyping revealed a high prevalence of the risk-associated C allele, with 45/63 cats (71.4%) carrying the GC genotype and 18/63 (28.6%) carrying the CC genotype, whereas the GG genotype was not detected, giving a Callele frequency of 64.3%. Obese cats had significantly greater body weight and VSAT thickness than normal-weight cats
5. 실험 설정
| 항목 | 내용 |
|---|---|
| 대상/재료 | Genotyping revealed a high prevalence of the risk-associated C allele, with 45/63 |
| 처리 조건 | Genotyping revealed a high prevalence of the risk-associated C allele, with 45/63 cats (71.4%) carrying the GC genotype and 18/63 (28.6%) carrying the CC genotype, whereas the GG genotype was not detected, giving a Callele frequency of 64.3% |
| 대조군 | - |
| 측정 방법 | Obese cats had significantly greater body weight and VSAT thickness than normal-weight cats |
6. 실험 결과 분석
| 지표 | 변화(Δ) | 조건 · 유의성 |
|---|---|---|
| - | - | Neuter status and ad libitum feeding were significantly associated with obesity, whereas diet type, housing, exercise frequency, and begging behavior were not |
제안 기전(인과 사슬): Neuter status and ad libitum feeding were significantly associated with obesity, whereas diet type, housing, exercise frequency, and begging behavior were not. Although genotype distribution did not differ significantly between normal and obese cohorts, obese CC cats showed significantly greater VSAT thickness than obese GC cats, indicating an allele-dosage effect on adiposity
7. 비판적 평가
강점
- These findings suggest that the POMC c.28G > C variant is a useful risk-informative marker and that combining genetic screening with objective fat assessment may support earlier identification and prevention of feline obesity in Vietnam under routine laboratory conditions and guide personalized management strategies in practice.
한계 · 의문
- 표본 크기 및 장기 추적 데이터 부재 가능성
8. 향후 연구 방향
- These findings suggest that the POMC c.28G > C variant is a useful risk-informative marker and that combining genetic screening with objective fat assessment may support earlier identification and prevention of feline obesity in Vietnam under routine laboratory conditions and guide personalized management strategies in practice.
9. 결론
Feline obesity is an increasingly important health problem influenced by both genetic predisposition and husbandry practices 연구에서 ventral subcutaneous adipose tissue (vsat) thickness was measured ultrasonographically as an objective indicator of adiposity을 통해 neuter status and ad libitum feeding were significantly associated with obesity, whereas diet type, housing, exercise frequency, and begging behavior were not. These findings suggest that the POMC c
Keywords
Prevalence, allele, associated, obesity, feline, population