Protective effects of three natural extracts on ovalbumin-induced intestinal and skin damage in felines
Protective effects of three natural extracts on ovalbumin-induced intestinal and skin damage in felines
- 저자: Wang Hengyan; Liu Tong; Bai Huasong; Jin Hongchen; Wang Zhanzhong
- 출처: Biochemistry and biophysics reports, 2026
- DOI/링크: 10.1016/j.bbrep.2026.102665
- 분야 태그: #반려동물 #동물건강
- 정리일: 2026-07-11
TL;DR
These findings demonstrate that HH exerts multi-target protective effects on the feline gut-skin axis, highlighting its potential as a therapeutic agent for managing allergic dermatitis associated with intestinal hypersensitivity
1. 연구 배경 및 동기
- 다루는 문제: The gut-skin axis plays a crucial role in mediating systemic immune and metabolic responses, particularly in allergic disorders
- 기존의 공백 / 왜 필요한가: This study investigated the protective effects of three natural extracts-Heartleaf Houttuynia P.E. (HH), green tea polyphenols (GTP), and Ginkgo biloba extract (GBE)-against ovalbumin (OVA)-induced intestinal and cutaneous damage in feline cells via the gut-skin axis
2. 관련 연구
- 기존 연구 흐름: Feline intestinal epithelial cells (FIECs) were exposed to OVA to establish an injury model, and their conditioned medium was transferred to feline skin cells (FSCs) to simulate inter-organ crosstalk
- 이 논문의 위치: Animal Health 분야 내 기존 문헌 검토
| 구분 | 기존 연구 | 이 논문 |
|---|---|---|
| 주제 | 일반적 접근 | Protective 중심 |
3. 핵심 기여
- HH intervention effectively reversed these alterations by restoring folate biosynthesis, nicotinate metabolism, glycerophospholipid metabolism, and nucleocytoplasmic transport, while suppressing pro-inflammatory lipid mediators and bacterial quorum signals
- Notably, HH modulated gut-skin communication by reprogramming both metabolic and transcriptional landscapes, thereby promoting cellular repair and homeostasis
- These findings demonstrate that HH exerts multi-target protective effects on the feline gut-skin axis, highlighting its potential as a therapeutic agent for managing allergic dermatitis associated with intestinal hypersensitivity.
4. 제안 방법론
- 전체 접근 논리: Among the tested compounds, all three extracts alleviated OVA-induced barrier dysfunction in both tissues, with HH exhibiting the strongest protective effects
- 단계: HH significantly attenuated OVA-induced inflammation (IL-1β, IL-6, TNF-α), oxidative stress (SOD, CAT, GSH, MDA), and disruption of barrier integrity (mucins, tight junction proteins, filaggrin, loricrin) in both FIECs and FSCs. Integrated metabolomic and transcriptomic analyses revealed that OVA disrupted core metabolic pathways-including pyrimidine metabolism, carbon metabolism, and quorum sensing-and activated inflammatory signaling networks such as TNF and IL-17
5. 실험 설정
| 항목 | 내용 |
|---|---|
| 대상/재료 | HH significantly attenuated OVA-induced inflammation (IL-1β, IL-6, TNF-α), oxidative stress (SOD, |
| 처리 조건 | HH significantly attenuated OVA-induced inflammation (IL-1β, IL-6, TNF-α), oxidative stress (SOD, CAT, GSH, MDA), and disruption of barrier integrity (mucins, tight junction proteins, filaggrin, loricrin) in both FIECs and FSCs |
| 대조군 | - |
| 측정 방법 | Integrated metabolomic and transcriptomic analyses revealed that OVA disrupted core metabolic pathways-including pyrimidine metabolism, carbon metabolism, and quorum sensing-and activated inflammatory signaling networks such as TNF and IL-17 |
6. 실험 결과 분석
| 지표 | 변화(Δ) | 조건 · 유의성 |
|---|---|---|
| - | - | HH intervention effectively reversed these alterations by restoring folate biosynthesis, nicotinate metabolism, glycerophospholipid metabolism, and nucleocytoplasmic transport, while suppressing pro-inflammatory lipid mediators and bacterial quorum signals |
제안 기전(인과 사슬): HH intervention effectively reversed these alterations by restoring folate biosynthesis, nicotinate metabolism, glycerophospholipid metabolism, and nucleocytoplasmic transport, while suppressing pro-inflammatory lipid mediators and bacterial quorum signals. Notably, HH modulated gut-skin communication by reprogramming both metabolic and transcriptional landscapes, thereby promoting cellular repair and homeostasis
7. 비판적 평가
강점
- These findings demonstrate that HH exerts multi-target protective effects on the feline gut-skin axis, highlighting its potential as a therapeutic agent for managing allergic dermatitis associated with intestinal hypersensitivity.
한계 · 의문
- 표본 크기 및 장기 추적 데이터 부재 가능성
8. 향후 연구 방향
- These findings demonstrate that HH exerts multi-target protective effects on the feline gut-skin axis, highlighting its potential as a therapeutic agent for managing allergic dermatitis associated with intestinal hypersensitivity.
9. 결론
The gut-skin axis plays a crucial role in mediating systemic immune and metabolic responses, particularly in allergic disorders 연구에서 among the tested compounds, all three extracts alleviated ova-induced barrier dysfunction in both tissues, with hh exhibiting the strongest protective effects을 통해 hh intervention effectively reversed these alterations by restoring folate biosynthesis, nicotinate metabolism, glycerophospholipid metabolism, and nucleocytoplasmic transport, while suppressing pro-inflammatory lipid mediators and bacterial quorum signals. These findings demonstrate that HH exerts multi-target protective effects on the feline gut-skin axis, highlighting its potential as a therapeutic agent for managing allergic dermatitis associated with intestinal hypersensitivity
Keywords
Protective, effects, three, natural, extracts, ovalbumin-induced